Doa ketika melihat cermin

MECHANISM OF MULTIPLE SCLEROSIS

During periods of multiple sclerosis activity, white blood cells (leukocytes) are drawn to regions of the white matter. These initiate and take part in what is known as the inflammatory response. The resulting inflammation is similar to what happens in your skin when you get a pimple.

During the inflammation, the myelin gets stripped from the axons in a process known as demyelination. The effect of this is quite similar to the rubber insulation on wire perishing - some or all of the electricity in the wire will short out and the efficient conductivity of the wire will be reduced. When the myelin sheath is damaged, the transmission of nerve impulses is slowed, stopped or can jump across into other demyelinated axons.

Additionally, the inflammation can also damage the underlying axonal membrane. This membrane is a sophisticated structure that enables the nerve transmission (the action potential) to travel along the nerve.

It seems that the inflammation also kills the mainenance glial cells, in particular it seems to kill the myelin-producing oligodendrocytes, which are lost in great numbers. Almost no oligodendrocytes persist in the middle of chronic MS lesions.

As the disease progresses, axons are also destroyed though not necessarily by the inflammatory

Read More

baca & kaji betul2... tengok realiti sebenar mcmna

myMetro | Penuntut liar